Decellularized extracellular matrix repair of volumetric muscle loss injury impairs adjacent bone healing in a rat model of complex musculoskeletal trauma.
RatFractureOpen tibiaLewismalen = n=10 total, n=5 per grouplocal surgical implantation into the volumetric muscle loss defectconcomitant with injury creation
Model: 3 mm segmental bone defect created concomitantly with a 6 mm full-thickness volumetric muscle loss injury to the tibialis anterior muscle, complex musculoskeletal trauma model
SIS-ECM repair of the volumetric muscle loss injury impaired adjacent open fracture healing, with significantly lower bone volume to total volume (27% lower at 6 weeks) versus no repair, and failed to improve tibialis anterior muscle strength, which showed similar deficits in both groups.
Extraction: extract · Subtype source: review · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.