Frontal Traumatic Brain Injury in Rats Causes Long-Lasting Impairments in Impulse Control That Are Differentially Sensitive to Pharmacotherapeutics and Associated with Chronic Neuroinflammation.
RatTBIControlled cortical impactLong-EvansMalen = 50 rats total: severe TBI n = 12, moderate TBI n = 13, mild…Intraperitoneal, 1 mL/kg in 0.9% sterile salineAmphetamine 0.0, 0.3, 0.6 and 1.0 mg/kg; atomoxetine 0.0, 0…Pharmacological challenges began after performance was statistically stable, ap…
Model: Bilateral frontal controlled cortical impact over medial prefrontal cortex (6.0 mm craniotomy, 5 mm flat tip, AP +3.0, ML 0.0); severe -2.5 mm at 3 m/s, moderate -1.7 mm at 2 m/s, mild -0.8 mm at 1 m/s, each 0.5 s dwell; intact sham
Injury severity produced graded, persistent deficits in attention, impulse control and task efficacy, with mild injury leaving persistent impulsivity only. Amphetamine impaired sham and TBI-resilient animals at higher doses but improved accuracy and reduced premature responding in chronically impai…
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