Reducing the time interval between concussion and voluntary exercise restores motor impairment, short-term memory, and alterations to gene expression.

Reducing the time interval between concussion and voluntary exercise restores motor impairment, short-term memory, and alterations to gene expression.

Model: Translational rodent model of concussion or mild traumatic brain injury

Exercise initiated 1 to 3 days after concussion significantly improved motor and cognitive function and restored injury-induced changes in gene expression in both brain regions, but had limited efficacy for emotional impairments. Animals deprived of social interaction and exercise did not recover,…

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