MDP: A Deinococcus Mn2+-Decapeptide Complex Protects Mice from Ionizing Radiation
MouseRadiationB6D2F1/JFemalen = 16 per groupSubcutaneous and oral300 mg DP1/kgPre-exposure (day -1 and 14 h before irradiation) and immediately post-irradiat…
Model: Whole-body gamma irradiation 9.5 Gy (LD70/30)
All 16 MDP-treated irradiated mice survived versus 63 percent lethality in vehicle-treated irradiated mice at 9.5 Gy; reduced morbidity, prevented bone marrow depletion and adipogenesis, preserved CD34 expression, ameliorated leukocytopenia, erythrocytopenia and splenomegaly, and upregulated G-CSF…
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