Inhibition of Prolyl Hydroxylase Attenuates Fas Ligand-Induced Apoptosis and Lung Injury in Mice.
MouseOtherC57BL/6MaleIntraperitoneal injection
Model: Acute lung injury induced by intratracheal instillation of Fas ligand
Dimethyloxalylglycine increased HIF-1 alpha and decreased Fas expression in lung tissue, attenuated caspase-3 activation and apoptotic cell death, reduced the increase in alveolar permeability after intratracheal Fas ligand, and lessened inflammatory responses and histopathological changes. The ant…
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