Paeonol Protects Rat Heart by Improving Regional Blood Perfusion during No-Reflow
RatIschaemia-reperfusionCardiacWistarMalen = 8 per groupOral (intragastric)100 mg/kg and 200 mg/kgPretreatment for 7 days before ischaemia-reperfusion
Model: Left anterior descending coronary artery ligation for 4 h followed by 8 h reperfusion
Paeonol significantly reduced infarct and no-reflow areas, improved regional myocardial perfusion and cardiac function, and lowered serum LDH, creatine kinase, cardiac troponin T and C-reactive protein
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