IL-4 drives microglia and macrophages toward a phenotype conducive for tissue repair and functional recovery after spinal cord injury.
MouseSpinal cord injuryContusionC57BL/6femaleintraspinal injectiondelayed single injection 48 hours after SCI
Model: contusion spinal cord injury
A single delayed intraspinal injection of IL-4 at 48 h after contusive SCI increased M2 marker expression in microglia and macrophages, induced resolution-phase macrophages, enhanced resolution of inflammation, improved functional outcomes and reduced tissue damage.
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