Nanoparticle-Delivered IRF5 siRNA Facilitates M1 to M2 Transition, Reduces Demyelination and Neurofilament Loss, and Promotes Functional Recovery After Spinal Cord Injury in Mice.
MouseSpinal cord injuryUnspecifiedLipidoid nanoparticle delivery to macrophages infiltrating the injury siteAfter spinal cord injury; macrophages isolated from the epicentre at day 3 were…
Model: Experimental spinal cord injury in mice
IRF5 rose from day 1, peaked at day 7 and fell thereafter, mirroring CD86. Nanoparticle delivery of IRF5 siRNA markedly reduced M1 and increased M2 macrophages in the wound, resolved inflammation, attenuated demyelination and neurofilament loss, and significantly improved locomotor function (p < 0.…
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