Pharmacological safety evaluation of a traditional herbal medicine Zereshk-e-Saghir and assessment of its hepatoprotective effects on carbon tetrachloride induced hepatic damage in rats.
MixedChemical/toxinNMRI (mice, lethality study)MaleOral gavage (CCl4 given intraperitoneally)250, 500, 750 and 1500 mg/kg for the hepatoprotection study…Pretreatment for 15 days before CCl4 challenge on day 16
Model: Carbon tetrachloride induced acute hepatic damage (1 ml/kg CCl4 in olive oil, intraperitoneal)
No mortality at single doses up to 2 g/kg and no significant haematotoxicity or hepatotoxicity after 15 days at 750 and 1500 mg/kg. Pretreatment at 250, 500 and 750 mg/kg reduced the CCl4-induced rise in ALT, AST and ALP, supported by histopathology, and decreased lipid peroxidation while maintaini…
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