Efficacy of a collagen-based dressing in an animal model of delayed wound healing.
MouseWounddb/dbTopical dressing applied to the wound
Model: Cutaneous wound in the db/db diabetic mouse model of delayed (chronic) wound healing
GBT013 improved wound epithelialisation compared with saline gauze in db/db mice, enhanced remodelling without signs of acute inflammation, significantly decreased IL-6 and IL-8, increased TIMP-1 and TIMP-2 mRNA, and reduced MMP-2 and MMP-9 activity in vitro.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.