Simvastatin Therapy in the Acute Stage of Traumatic Brain Injury Attenuates Brain Trauma-Induced Depression-Like Behavior in Rats by Reducing Neuroinflammation in the Hippocampus.
RatTBIFluid percussionSprague-DawleyMaleIntraperitoneal injection4, 10 or 20 mg/kg0, 24 and 48 h after traumatic brain injury
Model: Fluid percussion traumatic brain injury
Simvastatin 20 mg/kg given for 3 days significantly attenuated the increase in immobility duration on day 15 after injury and significantly reduced neuronal apoptosis, microglial and astrocyte activation and TNF-alpha expression in hippocampal CA3.
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