PrP(c) deficiency and dasatinib protect mouse intestines against radiation injury by inhibiting of c-Src.
MouseRadiationC57BL/6 wild-type and PrP(c)-deficient (knockout)
Model: Total body irradiation causing acute intestinal injury and epithelial barrier dysfunction
PrP(c) deficiency reduced radiation-induced lethality, improved intestinal wound healing and reduced intestinal leakage, and dasatinib treatment reproduced this protection, confirming Src involvement in acute intestinal radiation toxicity.
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