Topical Administration of Acylated Homoserine Lactone Improves Epithelialization of Cutaneous Wounds in Hyperglycaemic Rats.
RatWoundSprague-DawleyMaleTopical application to the wound10 microM, diluted in normal saline immediately before use…Applied on post-wounding day 4
Model: Two full-thickness excisional wounds on the flanks of rats made acutely hyperglycaemic by a single intraperitoneal injection of streptozotocin 55 to 60 mg/kg (blood glucose above 300 mg/dL)
Hyperglycaemic rats showed significantly shorter epithelialising tissue, fragmented and immature basement membrane, and abnormal basal keratinocyte proliferation. Topical AHL reduced basement membrane abnormalities, normalised the distribution of proliferating epidermal keratinocytes and significan…
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