Chronic Cognitive Dysfunction after Traumatic Brain Injury Is Improved with a Phosphodiesterase 4B Inhibitor.
RatTBIFluid percussionSprague-DawleyMaleAdministered at 3 months after surgery, before each behavioural task
Model: Moderate parasagittal fluid percussion traumatic brain injury
The selective PDE4B inhibitor significantly reversed injury-induced deficits in cue and contextual fear conditioning and water maze retention, reduced the deficit in basal synaptic transmission, rescued long-term potentiation expression, lowered TNF-alpha and increased phosphorylated CREB after inj…
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