Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3K/Akt/Nrf2 Pathway.
RatChemical/toxinSprague-DawleyMalen = 8 rats per groupIntravenous injection50 mg/kgPretreatment given before administration of the contrast medium
Model: Contrast-induced acute kidney injury produced by iohexol 10 mL/kg (3.5 gI/kg) via the tail vein in rats prepared by 5/6 nephrectomy
Intravenous salvianolic acid B pretreatment attenuated the rise in serum creatinine and the histological changes of tubular injury, reduced apoptosis-positive tubular cells, activated Nrf2 and lowered renal oxidative stress after iodinated contrast media. This renoprotection was abolished by the PI…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.