Nerve growth factor inhibition with tanezumab influences weight-bearing and subsequent cartilage damage in the rat medial meniscal tear model.
RatOtherLewisMalen = n=10 rats per group for histopathology; amputation study in…Subcutaneous0.1, 1 or 10 mg/kg per weekProphylactic arm started on the day of surgery (day 0); delayed-onset arm start…
Model: Medial meniscal tear (MMT) surgery of the knee, with additional delayed-treatment and mid-tibial amputation arms
Prophylactic tanezumab prevented the gait deficiency seen 3 to 7 days after MMT surgery and produced more severe cartilage damage, larger osteophytes, greater subchondral sclerosis and increased growth plate thickness in a time and dose related manner. Delaying treatment to 3 to 8 weeks after surge…
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