Anti-ulcerogenic effect of cavidine against ethanol-induced acute gastric ulcer in mice and possible underlying mechanism.
MouseChemical/toxinMaleIntragastric1, 5 or 10 mg/kgPre-treatment, 12 h and 1 h before ethanol administration
Model: Acute gastric ulcer induced by intragastric absolute ethanol (0.5 mL/100 g), animals euthanised 3 h after ethanol ingestion
Cavidine pre-treatment reduced macroscopic and histological gastric injury, lowered malondialdehyde, myeloperoxidase, interleukin-6 and tumour necrosis factor alpha, and raised mucosal glutathione, superoxide dismutase and prostaglandin E2 relative to the ethanol model group.
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