Traumatic brain injury decreases AMP-activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcome.
MixedTBIControlled cortical impactSprague-Dawley (rat); C57BL/6 (mouse)MaleAcute administration after injury
Model: Electromagnetic controlled cortical impact traumatic brain injury
Traumatic brain injury reduced AMPK phosphorylation at Thr172 and altered phosphorylation of downstream targets S6 and AS160. Post-injury treatment with AICAR or metformin did not affect spatial learning but significantly improved spatial memory, supporting a contribution of reduced AMPK activity t…
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