Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat.
RatTBIControlled cortical impactSprague-DawleyMaleIntravenous0.5 mg/kg or 0.1 mg/kg5 hours or 7 hours after injury
Model: Moderate to severe controlled cortical impact traumatic brain injury
Pomalidomide 0.5 mg/kg given 5 hours after injury significantly reduced injury volume and functional impairment, neurodegeneration, neuronal apoptosis and cytokine induction. The same dose at 7 hours, and 0.1 mg/kg at 5 hours, were not effective. In vitro, pomalidomide dose-dependently reduced glut…
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