A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries.
MouseTBIControlled cortical impactMaleIntravenousPhage library injected 6 hours after penetrating brain injury; CAQK homing dete…
Model: Penetrating brain injury and controlled cortical impact traumatic brain injury in mice; human cortical sections from a head trauma patient
CAQK selectively bound injured mouse and human brain and, injected systemically, homed to injury sites in both penetrating and controlled cortical impact models. Conjugation increased injury-site accumulation of payloads ranging from small molecules to nanoparticles, and CAQK-coated nanoparticles c…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.