Molecular Changes Associated with the Protective Effects of Angiopoietin-1 During Blood-Brain Barrier Breakdown Post-Injury.
RatTBICryogenicMaleIntra-corticalEarly post-injury, with assessment at day 1
Model: Cortical cold injury with blood-brain barrier breakdown and vasogenic oedema
Untreated cold-injured rats showed focal horseradish peroxidase leakage, increased endothelial caveolin-1 and decreased occludin in arterioles and venules with barrier breakdown, alongside increased Akt and ERK2. Angiopoietin-1 significantly reduced tracer leakage (P<0.001) and returned caveolin-1,…
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