Effect of exogenous surfactant instillation on experimental acute lung injury.
RatChemical/toxinIntratracheal instillationAfter NNNMU injury
Model: N-nitroso-N-methylurethane (NNNMU) induced acute lung injury in rats with chronic indwelling arterial catheters
Surfactant instillation improved oxygenation, reduced mortality to control values and restored the phospholipid-to-protein ratio, surface activity and individual phospholipid percentages, except phosphatidylglycerol, towards control values.
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