IL-17A promotes neutrophilic inflammation and disturbs acute wound healing in skin.
MouseWoundC57BL/6 (wild-type and IL-17A-knockout)Male and female
Model: Acute cutaneous (skin) wound in wild-type and IL-17A-knockout mice
IL-17A deficiency accelerated wound closure with greater myofibroblast differentiation and collagen deposition and fewer neutrophils, whereas administration of recombinant IL-17A delayed closure, lowered collagen deposition and increased neutrophil accumulation. Treating IL-17A-administered mice wi…
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