Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
MixedIschaemia-reperfusionCerebral (MCAO/stroke)Male
Model: Permanent middle cerebral artery occlusion (ischaemic stroke); in vitro LPS stimulation of primary microglia and astrocytes
ADAMTS-4 expression was raised in ischaemic brain of mice and of human stroke patients. Low-dose recombinant ADAMTS-4 before LPS reduced NO and pro-inflammatory cytokine production in primary microglia and astrocytes, while ADAMTS-4 silencing increased them. In vivo after permanent middle cerebral…
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