Ligand-mediated Galectin-1 endocytosis prevents intraneural H2O2 production promoting F-actin dynamics reactivation and axonal re-growth.

Ligand-mediated Galectin-1 endocytosis prevents intraneural H2O2 production promoting F-actin dynamics reactivation and axonal re-growth.

Model: Acute and chronic spinal cord injury model in vivo, with cultured neurons in vitro

Dimeric galectin-1 lowered hydrogen peroxide levels and restored F-actin dynamics in growth cones via carbohydrate-dependent co-internalisation with PlexinA4, and was associated with axonal re-growth, de novo synapse clustering, re-myelination and functional locomotor recovery in acute and chronic…

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.