A novel translocator protein 18 kDa ligand, ZBD-2, exerts neuroprotective effects against acute spinal cord injury.
MouseSpinal cord injuryCompressionC57BL/6Male10 mg/kg (described as high dose; at least one lower dose a…After spinal cord injury
Model: Acute traumatic spinal cord injury induced by spinal cord crush
ZBD-2 at 10 mg/kg improved hindlimb locomotor function, reduced tissue damage and preserved white matter; high-dose ZBD-2 reduced oxidative stress, increased spinal GAD67, raised phosphorylated Akt and lowered the Bax/Bcl-2 ratio, indicating neuroprotection through synaptic and PI3K/Akt mechanisms
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.