Poly-ADP-ribose polymerase inhibition provides protection against lung injury in a rat paraquat toxicity model.
RatChemical/toxinSprague-DawleyFemalen = 24 rats total across three groups10 mg/kg twice per dayFollowing paraquat administration
Model: Paraquat induced acute lung injury (15 mg/kg paraquat intraperitoneally)
Compared with paraquat alone, 3-aminobenzamide significantly lowered serum lactate dehydrogenase and neopterin, tissue oxidative stress parameters, TGF-beta1 and histological injury scores, and significantly increased total antioxidant capacity, suggesting PARP inhibition minimises paraquat induced…
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