Inhibition of microtubule dynamics impedes repair of kidney ischemia/reperfusion injury and increases fibrosis.
MouseIschaemia-reperfusionRenalC57BL/6Malen = A minimum of six mice per experimental groupIntraperitonealPaclitaxel 0.3 mg/kg body weight; colchicine 0.1 mg/kg body…Started on day 1 after ischaemia induction, during the recovery phase after the…
Model: Bilateral renal ischaemia/reperfusion, renal pedicles clamped for 30 min followed by reperfusion
Ischaemia/reperfusion caused alpha-tubulin deacetylation with loss of alpha-TAT1. Paclitaxel given during the recovery phase increased tubulin acetylation, raised p21 and p-chk2, reduced BrdU-positive tubule cells while increasing BrdU-positive interstitial cells, delayed BUN and body weight recove…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.