PRECLINICAL PUBLICATION · 2016

Anti-Inflammation Effects and Potential Mechanism of Saikosaponins by Regulating Nicotinate and Nicotinamide Metabolism and Arachidonic Acid Metabolism.

Mouse / Chemical/toxin

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Saikosaponins (main active constituent of Radix Bupleuri)

PMID 27251379 ↗2016Reported benefit

Anti-Inflammation Effects and Potential Mechanism of Saikosaponins by Regulating Nicotinate and Nicotinamide Metabolism and Arachidonic Acid Metabolism.

MouseChemical/toxin

Model: Acute inflammation induced by subcutaneous injection of formalin into the hind paw

Saikosaponins reduced formalin-induced paw oedema and shifted 12 disturbed metabolites, including nicotinate, niacinamide, arachidonic acid and 20-carboxy-leukotriene B4, back towards the normal range.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.