Proteomic Analysis of the Spatio-temporal Based Molecular Kinetics of Acute Spinal Cord Injury Identifies a Time- and Segment-specific Window for Effective Tissue Repair.
RatSpinal cord injuryUnspecifiedOne hour after spinal cord injury
Model: Acute spinal cord injury with rostral and caudal segment sampling (R1-C1, R2-C2, R3-C3)
Anti-CD20 given one hour after injury did not improve locomotor function and did not decrease immunoglobulin G expression. The main contribution of the paper is a spatio-temporal proteomic map indicating the caudal C1 segment as a candidate therapeutic target.
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