Pharmacological inhibition of MyD88 homodimerization counteracts renal ischemia reperfusion-induced progressive renal injury in vivo and in vitro.
MouseIschaemia-reperfusionRenalBALB/c (wild-type), with BALB/c MyD88 knockout and C57BL/6 mice also usedMalen = Not explicitly stated; the reported 58.3% survival is consi…Intraperitoneal injectionTJ-M2010-2 50 mg/kg dissolved in 0.5% carboxymethyl cellulo…Pre-treatment starting two days before surgery
Model: Unilateral renal ischaemia reperfusion; 80 min ischaemia with uninephrectomy for short-term observation up to 7 days, and 60 min ischaemia without nephrectomy for 28-day observation
All untreated mice died within five days of 80 min ischaemia with uninephrectomy, whereas TJ-M2010-2 alone raised survival to 58.3% and combined TJ-M2010-2 plus MR1 to 100% at 28 days. Treatment normalised creatinine and blood urea nitrogen by day 7, reduced tubular necrosis, inflammatory cytokines…
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