Early Intravenous Delivery of Human Brain Stromal Cells Modulates Systemic Inflammation and Leads to Vasoprotection in Traumatic Spinal Cord Injury.
RatSpinal cord injuryCompressionWistarFemaleIntravenousEarly after injury
Model: C7-T1 clip compression spinal cord injury using a 35-gram clip
Approximately 0.001 to 0.002 per cent of infused cells reached the spinal cord, with most residing in lung, liver and spleen, and a persistent splenic population at 7 days. Infusion raised splenic and circulating interleukin-10, reduced acute blood spinal cord barrier permeability, haemorrhage and…
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