Synthetic niche to modulate regenerative potential of MSCs and enhance skeletal muscle regeneration.
RatOtherSprague-DawleyFemale
Model: Severe skeletal muscle trauma (clinically relevant acute muscle injury model; specific procedure not stated in the abstract)
MSCs delivered in growth factor loaded alginate cryogels significantly improved muscle function, remodelled scar tissue and promoted new myofibre formation, outperforming cell delivery or growth factor delivery alone.
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.