The protein PprI provides protection against radiation injury in human and mouse cells.
MixedRadiationBALB/cMalen = 10 mice per group for the 30-day mortality study; 12 mice p…Intraperitoneal injection in mice; added to culture medium in vitro100 micrograms/kg in mice; 4 micrograms/mL in HUVEC cultureMice dosed 1 h before, 1 h after and 24 h after irradiation; HUVECs pretreated…
Model: Acute whole-body gamma irradiation from a cobalt-60 source at 6 Gy (30-day mortality) or 4 Gy (haematology, bone marrow clonogenic assay, organ histopathology and antioxidant assays) at 2 Gy/min; HUVECs irradiated at 2 or 4 Gy at 0.38 Gy/min
PprI reduced 30-day mortality after 6 Gy from 50% to 20%, improved white blood cell and lymphocyte counts on day 7 and platelet counts on days 7 and 14, increased bone marrow colony formation, limited histopathological damage to lung, liver, kidney and testis, and raised superoxide dismutase and ca…
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