Role of nicotinamide (vitamin B3) in acetaminophen-induced changes in rat liver: Nicotinamide effect in acetaminophen-damged liver.
RatChemical/toxinWistarMale500 mg/kg body weightSingle dose given either before or after acetaminophen intoxication
Model: Acute liver injury induced by an acetaminophen overdose of 5 g/kg body weight
Nicotinamide given after intoxication significantly ameliorated acetaminophen-induced biochemical changes and hepatic pathology, but the same dose given to healthy animals or before intoxication was itself hepatotoxic.
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