Disruption of Locomotion in Response to Hindlimb Muscle Stretch at Acute and Chronic Time Points after a Spinal Cord Injury in Rats.
RatSpinal cord injuryContusionSprague-DawleyFemalePhysical intervention applied to hindlimbs24-minute stretching protocol per sessionStarted 4 days after injury (acute cohort) or 10 weeks after injury (chronic co…
Model: T10 contusion spinal cord injury at 25 g-cm
Stretching impaired locomotor recovery. Deficits appeared after only 5 days in the acute cohort and worsened with greater perceived stretch intensity at week 4. Chronic stretching produced BBB scores of 0 to 3 during weeks 2 to 4. Function recovered to control levels within 2 weeks of stopping stre…
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