Topical Therapy with Mesenchymal Stem Cells Following an Acute Experimental Head Injury Has Benefits in Motor-Behavioral Tests for Rodents.
RatTBIControlled cortical impactSprague-Dawley, with donor cells from transgenic green fluorescent protein Sprague-Dawley ratsMalen = 10 test animals and 10 control animalsTopical application to the exposed cerebral cortex at the injured site, held in place by a thin fibrin layer1.5 million cells per animalApplied at the time of injury during the same procedure
Model: Controlled cortical impact traumatic brain injury delivered by an electromagnetically controlled device after craniotomy between bregma and lambda, 1 mm lateral to the midline
Within 5 days of topical application, green fluorescent protein positive cells were found in brain parenchyma co-expressing glial fibrillary acidic protein, nestin and NeuN. Treated animals showed less neuronal death in hippocampal CA1 and CA3 and significantly improved neurological functional reco…
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