ErbB2 blockade with Herceptin (trastuzumab) enhances peripheral nerve regeneration after repair of acute or chronic peripheral nerve injury.
RatOtherSprague-DawleyMaleAdministered after nerve transection and repair
Model: Common peroneal nerve transection with immediate repair or repair after 4 months of chronic denervation
Trastuzumab increased the rate of motor and sensory neuron regeneration, Schwann cell proliferation in the distal stump, and the number of myelinated axons regenerating after both immediate and delayed repair.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.