PRECLINICAL PUBLICATION · 2016

E-Prostanoid 2 Receptor Overexpression Promotes Mesenchymal Stem Cell Attenuated Lung Injury.

Mouse / Endotoxin/LPS

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Mesenchymal stem cells transduced with a lentiviral vector carrying the E-prostanoid 2 receptor gene (MSCs-EP2)

PMID 27158855 ↗2016Reported benefit

E-Prostanoid 2 Receptor Overexpression Promotes Mesenchymal Stem Cell Attenuated Lung Injury.

MouseEndotoxin/LPSC57BL/6Male

Model: Lipopolysaccharide-induced acute lung injury (acute respiratory distress syndrome model)

MSCs-EP2 showed enhanced homing to injured lung and reduced pulmonary vascular permeability and pro-inflammatory cytokine levels compared with MSCs-GFP.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.