Optically-Induced Neuronal Activity Is Sufficient to Promote Functional Motor Axon Regeneration In Vivo.
MouseOtherC57BL/6J thy-1-ChR2/YFP transgenicMalen = 17 optically treated and 10 untreated for EMG at 3 weeks; 5…Direct application to the exposed sciatic nerve via fibre optic cable1 ms pulses at 20 Hz, supramaximal intensity approximately…1 h of continuous optical stimulation immediately prior to nerve transection an…
Model: Bilateral sciatic nerve transection with end-to-end repair secured using fibrin glue
A single 1 h optical treatment increased EMG responses, motor endplate re-occupation and the number of regenerating motoneurons at 4 weeks, with the effect confined to optically activated ChR2-positive axons.
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