Regulatory T Cells Contribute to the Inhibition of Radiation-Induced Acute Lung Inflammation via Bee Venom Phospholipase A2 in Mice.
MouseRadiationC57BL/6Femalen = 7 to 10 per group in the main experiment; 5 per group in th…Intraperitoneal0.2 mg/kg body weightFirst dose on day 7 after irradiation
Model: Focal irradiation of the left lung with a single 75 Gy fraction of X-rays (X-RAD 320, 3 mm collimator)
bvPLA2 reduced immune cell accumulation, inflammatory and fibrotic gene expression and histological lung damage after thoracic irradiation, and the effect was abolished by regulatory T cell depletion.
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