Cerium Oxide Nanoparticles: A Potential Medical Countermeasure to Mitigate Radiation-Induced Lung Injury in CBA/J Mice.
MouseRadiationCBA/JFemalen = 10 per groupIntraperitonealLow dose 100 nM (0.00007 mg/kg) and high dose 10 microM (0.…First dose 2 h after irradiation
Model: Single 15 Gy whole-thorax irradiation at a dose rate of 69 cGy/min (320 kVp, 10 mA, HVL 1.00 mm Cu)
High-dose CNP-18 increased survival to 90 per cent versus 10 per cent with radiation alone and reduced fibrosis, inflammation and vascular damage, whereas low-dose CNP-18 and both CNP-ME doses gave limited benefit.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.