PRECLINICAL PUBLICATION · 2016

15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy.

Mouse / Chemical/toxin

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2)

PMID 27133055 ↗2016Reported benefit

15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy.

MouseChemical/toxinBALB/cMale2.5 to 10 micrograms30 min after concanavalin A injection

Model: Concanavalin A-induced acute fulminant hepatitis (25 mg/kg concanavalin A injection)

15d-PGJ2 reduced histological liver injury, pro-inflammatory cytokines and reactive oxygen species, and inhibited hepatocyte apoptosis and autophagy via Nrf2 and HO-1 up-regulation.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.