Lentivirus-mediated PGC-1alpha overexpression protects against traumatic spinal cord injury in rats.
RatSpinal cord injuryContusionSprague-DawleyMaleIntraspinal injection at rostral and caudal sites 3 mm from the lesion epicentreImmediately after injury
Model: Contusive traumatic spinal cord injury
PGC-1alpha gene delivery reduced apoptosis, increased neuronal survival and axonal regeneration markers, and improved hindlimb locomotor recovery after contusive spinal cord injury.
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