Contribution of dermal-derived mesenchymal cells during liver repair in two different experimental models.
MouseChemical/toxinC57BL/6J recipients; EGFP-transgenic CByJ.B6-Tg(CAG-EGFP)1Osb/J donorsMale recipients; donor sex not statedHepatic portal vein (fibrosis model); tail vein (irradiation model)Week 6 of a 10 week CCl4 regimen; 4 h after 8 Gy total-body irradiation
Model: CCl4-induced liver fibrosis (0.6 ml/kg intraperitoneally twice weekly for 10 weeks) and 8 Gy lethal total-body irradiation
DMCs transplantation reduced CCl4-induced fibrosis and restored liver function, and improved survival after 8 Gy total-body irradiation, with long-term hepatic engraftment of a macrophage-like DMC population.
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