Nuclear factor erythroid-2 related factor 2 overexpressed mesenchymal stem cells transplantation, improves renal function, decreases injuries markers and increases repair markers in glycerol-induced Acute kidney injury rats.
RatChemical/toxinMaleAfter confirmation of acute kidney injury at 24 h following glycerol injection
Model: Glycerol-induced (rhabdomyolysis) acute kidney injury; 50% glycerol 8 ml/kg injected into the left and right hind femoral muscles after water deprivation
Transplantation of Nrf2-overexpressing mesenchymal stem cells lowered blood urea nitrogen and creatinine and improved kidney regeneration over 14 days, with upregulation of repair markers and downregulation of injury markers, exceeding the effect of unmodified mesenchymal stem cells.
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