Effectiveness of minocycline and FK506 alone and in combination on enhanced behavioral and biochemical recovery from spinal cord injury in rats.
RatSpinal cord injuryCompressionMaleOralMinocycline 50 mg/kg; FK506 1 mg/kg
Model: Experimental spinal cord injury by weight compression method
Both drugs produced significant behavioural recovery, supported by histopathological, monoamine and oxidative stress findings, with the ranking FK506 plus minocycline greater than minocycline greater than FK506 across all parameters.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.