Microsomal prostaglandin E synthase-1 protects against Fas-induced liver injury.
MouseChemical/toxinMaleTransgenic hepatic expression; Jo2 given intraperitoneallyConstitutive transgene expression before injury
Model: Fas-induced acute liver injury by intraperitoneal anti-Fas antibody Jo2
mPGES-1 transgenic mice showed less hepatic haemorrhage, lower ALT and AST and less necrosis and apoptosis after Jo2 challenge, with protection abolished by mPGES-1 or Akt inhibition.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.