The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats.
RatOtherSprague-Dawley (infraorbital nerve and oxaliplatin models); Wistar (streptozotocin model)MaleIntraperitoneal20, 40 or 80 mg/kgDay 25 after infraorbital nerve constriction; from day 21 after streptozotocin;…
Model: Chronic constriction injury of the infraorbital nerve; streptozotocin-induced diabetic polyneuropathy; oxaliplatin-induced polyneuropathy
E-52862 dose-dependently reduced mechanical allodynia, mechanical hyperalgesia and cold allodynia across the three models, with increased rather than diminished effect after 7 days of twice-daily dosing.
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