delta-Ctenitoxin-Pn1a, a Peptide from Phoneutria nigriventer Spider Venom, Shows Antinociceptive Effect Involving Opioid and Cannabinoid Systems, in Rats.
RatOtherWistarMaleIntrathecal and intraplantar0.25 to 2 micrograms per site intrathecally; 5 micrograms p…2 h 30 min after carrageenan; 2 h 55 min after prostaglandin E2; 14 days after…
Model: Carrageenan-induced inflammatory pain; sciatic nerve constriction neuropathic pain; prostaglandin E2-induced acute pain
delta-Ctenitoxin-Pn1a produced dose-dependent antinociception in inflammatory, neuropathic and acute pain models, blocked by CB1 and by mu and delta opioid receptor antagonists.
Extraction: extract · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.